Journal: AAPS PharmSciTech

Article Title: Soluble Itraconazole in Tablet Form Using Disordered Drug Delivery Approach: Critical Scale-up Considerations and Bio-equivalence Studies

doi: 10.1208/s12249-012-9918-9

Figure Lengend Snippet: Comparative dissolution profiles for optimization of drug/HPMC ratio (a) and pellet dimension (b). The weight of pellets was always maintained constant in the process. Dissolution was performed by using an equivalent of 100 mg of itraconazole

Article Snippet: An open label, balanced, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study of single dose of two ITZ tablets 100 mg (each tablet contains itraconazole 100 mg) and two Orungal capsules 100 mg of Janssen Pharmaceutica (brand equivalent of Sporanox) in healthy human adult male subjects under fed condition was carried out as per the approved protocol.

Techniques:

Journal: AAPS PharmSciTech

Article Title: Soluble Itraconazole in Tablet Form Using Disordered Drug Delivery Approach: Critical Scale-up Considerations and Bio-equivalence Studies

doi: 10.1208/s12249-012-9918-9

Figure Lengend Snippet: X-ray diffraction studies, A ITZ, B physical mixture (ITZ + excipients involved), C glass system, D MUPS and E tablet. Disappearance of critical peaks of itraconazole symbolizes formation of disordered system

Article Snippet: An open label, balanced, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study of single dose of two ITZ tablets 100 mg (each tablet contains itraconazole 100 mg) and two Orungal capsules 100 mg of Janssen Pharmaceutica (brand equivalent of Sporanox) in healthy human adult male subjects under fed condition was carried out as per the approved protocol.

Techniques:

Journal: AAPS PharmSciTech

Article Title: Soluble Itraconazole in Tablet Form Using Disordered Drug Delivery Approach: Critical Scale-up Considerations and Bio-equivalence Studies

doi: 10.1208/s12249-012-9918-9

Figure Lengend Snippet: SEM studies, A ITZ + excipients involved, B glass system, C1 and C2 MUPS, D1 and D2 Sporanox

Article Snippet: An open label, balanced, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study of single dose of two ITZ tablets 100 mg (each tablet contains itraconazole 100 mg) and two Orungal capsules 100 mg of Janssen Pharmaceutica (brand equivalent of Sporanox) in healthy human adult male subjects under fed condition was carried out as per the approved protocol.

Techniques:

Journal: AAPS PharmSciTech

Article Title: Soluble Itraconazole in Tablet Form Using Disordered Drug Delivery Approach: Critical Scale-up Considerations and Bio-equivalence Studies

doi: 10.1208/s12249-012-9918-9

Figure Lengend Snippet: In vitro dissolution studies of the developed tablet formulation vis-à-vis Innovator Sporanox

Article Snippet: An open label, balanced, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study of single dose of two ITZ tablets 100 mg (each tablet contains itraconazole 100 mg) and two Orungal capsules 100 mg of Janssen Pharmaceutica (brand equivalent of Sporanox) in healthy human adult male subjects under fed condition was carried out as per the approved protocol.

Techniques: In Vitro

Journal: AAPS PharmSciTech

Article Title: Soluble Itraconazole in Tablet Form Using Disordered Drug Delivery Approach: Critical Scale-up Considerations and Bio-equivalence Studies

doi: 10.1208/s12249-012-9918-9

Figure Lengend Snippet: The Unit Formula per Tablet for Coating of Pellets: A 20% Overage Was Added to Compensate for Process Loss

Article Snippet: An open label, balanced, randomized, two-treatment, two-period, two-sequence, crossover bioequivalence study of single dose of two ITZ tablets 100 mg (each tablet contains itraconazole 100 mg) and two Orungal capsules 100 mg of Janssen Pharmaceutica (brand equivalent of Sporanox) in healthy human adult male subjects under fed condition was carried out as per the approved protocol.

Techniques:

Journal: International Journal of Nanomedicine

Article Title: Lung-Targeted Itraconazole Delivery Using PVA-Based Nano-in-Microparticles for Improved Treatment of Pulmonary Aspergillosis

doi: 10.2147/IJN.S511099

Figure Lengend Snippet: Formulation of Itraconazole (ITZ) Nanoparticles-in-Microparticles (NIM)

Article Snippet: Itraconazole (ITZ) was purchased from SMS Pharmaceuticals Ltd. (India).

Techniques: Formulation, Nano-Suspension